ZO Skin Health
ZO Skin Health is the medical-grade line developed by dermatologist Dr. Zein Obagi, built on high concentrations of retinol, antioxidants and peptides. Its multi-step protocols cleanse, exfoliate and protect, and the range addresses aging, acne, sun damage and inflammation. Our med spa team at Mafi Plastic Surgery in Fresno, California selects the products your skin needs.
Book a consultationWhat is
ZO Skin Health?
ZO Skin Health was developed by Dr. Zein Obagi, a renowned dermatologist, and the range is built around restoring skin health at a cellular level rather than around one complaint at a time. It addresses aging, acne, sun damage and inflammation.
The line runs from powerful exfoliators through serums and cleansers to sunscreen formulations, and what they do together is improve skin texture, tone and overall clarity.
What makes it medical-grade is the concentration. ZO is formulated with high concentrations of active ingredients like retinol, antioxidants and peptides, clinically tested and made to penetrate deeper than what you buy over the counter, which is why it is dispensed through licensed professionals instead of sold off a shelf.
The products are meant to be used in multi-step protocols that cleanse, exfoliate and protect, with the emphasis on promoting the skin’s own regeneration and repair. That is why a ZO routine is put together as a protocol rather than picked up one bottle at a time.
Our med spa team at Mafi Plastic Surgery in Fresno selects the ZO products that belong in your routine, after looking at your skin and hearing what has actually been bothering you.
The line carries high concentrations of active ingredients, which is the difference between medical-grade skin care and what is sold over the counter.
ZO products are built to work as a protocol that cleanses, exfoliates and protects, rather than as single products used in isolation.
The focus of the range is restoring skin health at a cellular level, promoting the skin’s own regeneration and repair.
Medical-grade lines are available through licensed professionals, so your ZO products are selected for you here and belong to a routine rather than to a shelf.
Is ZO Skin Health right for me?
Skin health, restored at the cellular level.
Nothing is selected until our med spa team has looked at your skin. ZO may be the right line for you if any of these describe you:
Signs of Aging
Lines and loss of tone that you would like a daily routine working on.
Acne
Breakouts you want addressed with medical-grade actives rather than with what is on the shelf.
Sun Damage
Years of sun that show on your skin and have never been properly treated.
Inflammation
Skin that runs irritated and inflamed, one of the concerns the line is formulated to address.
Texture, Tone and Clarity
You want the surface of your skin more even and clearer, not simply better covered.
Ready for a Protocol
ZO works in multi-step protocols, so it suits you if you will use a routine daily rather than occasionally.
Common questions about ZO Skin Health
There is no single number, because a protocol is several products and yours is built from what your skin needs rather than from a set list. You are told what is recommended and what it costs before you buy anything. Mafi Plastic Surgery works with CareCredit, Cherry and PatientFi, and CareCredit can be used again and again for skin care as well as for treatments, so a full routine does not have to land in one payment.
What does a ZO protocol cost, and can I pay over time?
There is no single number, because a protocol is several products and yours is built from what your skin needs rather than from a set list. You are told what is recommended and what it costs before you buy anything. Mafi Plastic Surgery works with CareCredit, Cherry and PatientFi, and CareCredit can be used again and again for skin care as well as for treatments, so a full routine does not have to land in one payment.
Build Your
Protocol
See our med spa team in Fresno to find out which parts of the ZO line your skin actually needs, and which it does not.
Prefer to talk? Call (559) 890-6500.
Medically reviewed by Parham Mafi, M.D., F.A.C.S., board-certified plastic surgeon at Mafi Plastic Surgery. This page is for education and is not a substitute for a personalized medical consultation.
Last medically reviewed August 2026Updated